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1

Synthetic Lethal Vulnerabilities of Cancer

Fece de la Cruz, Ferran, Gapp, Bianca V., Nijman, Sebastian M.B.

Journal:

Annual Review of Pharmacology

Year:

2015

Language:

english

File:

PDF, 828 KB

english, 2015

2

p19ARF/p14ARF controls oncogenic functions of signal transducer and activator of transcription 3 in hepatocellular carcinoma

Doris Schneller, Georg Machat, Alexandra Sousek, Verena Proell, Franziska van Zijl, Gudrun Zulehner, Heidemarie Huber, Markus Mair, Markus K. Muellner, Sebastian M.B. Nijman, Robert Eferl, Richard Mor

Journal:

Year:

2011

Language:

english

File:

PDF, 3.03 MB

english, 2011

3

10.1038/24884

Bos, Johannes L., de Rooij, Johan, Zwartkruis, Fried J. T., Verheijen, Mark H. G., Cool, Robbert H., Nijman, Sebastian M. B., Wittinghofer, Alfred

Journal:

Year:

1998

Language:

english

File:

PDF, 489 KB

english, 1998

4

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

Brummelkamp, Thijn R., Nijman, Sebastian M. B., Dirac, Annette M. G., Bernards, René

Journal:

Year:

2003

Language:

english

File:

PDF, 392 KB

english, 2003

5

Global gene disruption in human cells to assign genes to phenotypes by deep sequencing

Carette, Jan E, Guimaraes, Carla P, Wuethrich, Irene, Blomen, Vincent A, Varadarajan, Malini, Sun, Chong, Bell, George, Yuan, Bingbing, Muellner, Markus K, Nijman, Sebastian M

Journal:

Nature Biotechnology

Year:

2011

Language:

english

File:

PDF, 1.72 MB

english, 2011

6

Regulation of monoubiquitinated PCNA by DUB autocleavage

Huang, Tony T., Nijman, Sebastian M.B., Mirchandani, Kanchan D., Galardy, Paul J., Cohn, Martin A., Haas, Wilhelm, Gygi, Steven P., Ploegh, Hidde L., Bernards, René, D'Andrea, Alan D.

Journal:

Nature Cell Biology

Year:

2006

Language:

english

File:

PDF, 1.89 MB

english, 2006

7

High-content screens: Giving Rho(d) directions

Muellner, Markus K, Nijman, Sebastian M B

Journal:

Nature Chemical Biology

Year:

2010

Language:

english

File:

PDF, 1.16 MB

english, 2010

8

Synthetic lethality: General principles, utility and detection using genetic screens in human cells

Sebastian M.B. Nijman

Journal:

Year:

2011

Language:

english

File:

PDF, 603 KB

english, 2011

9

Identification of Oncostatin M as a STAT5-Dependent Mediator of Bone Marrow Remodeling in KIT D816V-Positive Systemic Mastocytosis

Gregor Hoermann, Sabine Cerny-Reiterer, Andrea Perné, Miriam Klauser, Konrad Hoetzenecker, Katharina Klein, Leonhard Müllauer, Marion Gröger, Sebastian M.B. Nijman, Walter Klepetko, Peter Valent, Matt

Journal:

The American Journal of Pathology

Year:

2011

Language:

english

File:

PDF, 2.93 MB

english, 2011

10

A Genomic and Functional Inventory of Deubiquitinating Enzymes

Sebastian M.B. Nijman, Mark P.A. Luna-Vargas, Arno Velds, Thijn R. Brummelkamp, Annette M.G. Dirac, Titia K. Sixma, René Bernards

Journal:

Year:

2005

Language:

english

File:

PDF, 1.15 MB

english, 2005

11

The Deubiquitinating Enzyme USP1 Regulates the Fanconi Anemia Pathway

Sebastian M.B. Nijman, Tony T. Huang, Annette M.G. Dirac, Thijn R. Brummelkamp, Ron M. Kerkhoven, Alan D. D'Andrea, René Bernards

Journal:

Year:

2005

Language:

english

File:

PDF, 619 KB

english, 2005

12

Functional drug–gene interactions in lung cancer

Smida, Michal, Nijman, Sebastian MB

Journal:

Expert Review of Molecular Diagnostics

Year:

2012

Language:

english

File:

PDF, 795 KB

english, 2012

13

Exploiting epigenetic vulnerabilities for cancer therapeutics

Mair, Barbara, Kubicek, Stefan, Nijman, Sebastian M.B.

Journal:

Trends in Pharmacological Sciences

Year:

2014

Language:

english

File:

PDF, 443 KB

english, 2014

14

TOPS: a versatile software tool for statistical analysis and visualization of combinatorial gene-gene and gene-drug interaction screens

Muellner, Markus K, Duernberger, Gerhard, Ganglberger, Florian, Kerzendorfer, Claudia, Uras, Iris Z, Schoenegger, Andreas, Bagienski, Klaudia, Colinge, Jacques, Nijman, Sebastian MB

Journal:

BMC Bioinformatics

Year:

2014

Language:

english

File:

PDF, 1.48 MB

english, 2014

15

A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer

Muellner, Markus K, Uras, Iris Z, Gapp, Bianca V, Kerzendorfer, Claudia, Smida, Michal, Lechtermann, Hannelore, Craig-Mueller, Nils, Colinge, Jacques, Duernberger, Gerhard, Nijman, Sebastian M B

Journal:

Nature Chemical Biology

Year:

2011

Language:

english

File:

PDF, 764 KB

english, 2011

16

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

Essletzbichler, Patrick, Konopka, Tomasz, Santoro, Federica, Chen, Doris, Gapp, Bianca V., Kralovics, Robert, Brummelkamp, Thijn R., Nijman, Sebastian M.B., Bürckstümmer, Tilmann

Journal:

Genome Research

Year:

2014

Language:

english

File:

PDF, 1009 KB

english, 2014

17

Functional genomics to uncover drug mechanism of action

Nijman, Sebastian M B

Journal:

Nature Chemical Biology

Year:

2015

Language:

english

File:

PDF, 1.02 MB

english, 2015

18

A generic strategy for CRISPR-Cas9-mediated gene tagging

Lackner, Daniel H., Carré, Alexia, Guzzardo, Paloma M., Banning, Carina, Mangena, Ramu, Henley, Tom, Oberndorfer, Sarah, Gapp, Bianca V., Nijman, Sebastian M.B., Brummelkamp, Thijn R., Bürckstümmer, T

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 572 KB

english, 2015

19

Comparison of genetic variants in matched samples using thesaurus annotation

Konopka, Tomasz, Nijman, Sebastian M.B.

Journal:

Year:

2016

Language:

english

File:

PDF, 496 KB

english, 2016

20

Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells

Forment, Josep V, Herzog, Mareike, Coates, Julia, Konopka, Tomasz, Gapp, Bianca V, Nijman, Sebastian M, Adams, David J, Keane, Thomas M, Jackson, Stephen P

Journal:

Nature Chemical Biology

Year:

2016

Language:

english

File:

PDF, 402 KB

english, 2016

21

Parallel reverse genetic screening in mutant human cells using transcriptomics

Gapp, Bianca V, Konopka, Tomasz, Penz, Thomas, Dalal, Vineet, Bürckstümmer, Tilmann, Bock, Christoph, Nijman, Sebastian MB

Journal:

Molecular Systems Biology

Year:

2016

Language:

english

File:

PDF, 2.57 MB

english, 2016

22

Discovery of a highly selective cell-active inhibitor of KDM2/7

Gerken, Philip, Wolstenhulme, Jamie, Tumber, Anthony, Hatch, Stephanie, Zhang, Yijia, Müller, Susanne, Chandler, Shane, Mair, Barbara, Li, Fengling, Nijman, Sebastian, Konietzny, Rebecca, Szommer, Tam

Journal:

Angewandte Chemie International Edition

Year:

2017

Language:

english

File:

PDF, 1.20 MB

english, 2017

23

Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7

Gerken, Philip A., Wolstenhulme, Jamie R., Tumber, Anthony, Hatch, Stephanie B., Zhang, Yijia, Müller, Susanne, Chandler, Shane A., Mair, Barbara, Li, Fengling, Nijman, Sebastian M. B., Konietzny, Reb

Journal:

Angewandte Chemie

Year:

2017

Language:

english

File:

PDF, 1.97 MB

english, 2017

24

Cardiac Glycosides Induce Cell Death in Human Cells by Inhibiting General Protein Synthesis

Perne, Andrea, Muellner, Markus K., Steinrueck, Magdalena, Craig-Mueller, Nils, Mayerhofer, Julia, Schwarzinger, Ilse, Sloane, Mathew, Uras, Iris Z., Hoermann, Gregor, Nijman, Sebastian M. B., Mayerho

Journal:

Year:

2009

Language:

english

File:

PDF, 697 KB

english, 2009

25

Ubiquitin-Specific Protease 4 Inhibits Mono-Ubiquitination of the Master Growth Factor Signaling Kinase PDK1

Uras, Iris Z., List, Thomas, Nijman, Sebastian M. B., Jin, Dong-Yan

Journal:

Year:

2012

Language:

english

File:

PDF, 1.12 MB

english, 2012

26

Large-Scale Trade in Legally Protected Marine Mollusc Shells from Java and Bali, Indonesia

Nijman, Vincent, Spaan, Denise, Nekaris, K. Anne-Isola, Ferse, Sebastian C. A.

Journal:

Year:

2015

Language:

english

File:

PDF, 743 KB

english, 2015

27

Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway

De Zan, Erica, van Stiphout, Ruud, Gapp, Bianca V., Blomen, Vincent A., Brummelkamp, Thijn R., Nijman, Sebastian M.B.

Journal:

Science Signaling

Year:

2020

File:

PDF, 1.10 MB

2020

28

Perturbation-Driven Entropy as a Source of Cancer Cell Heterogeneity

Nijman, Sebastian M.B.

Journal:

Trends in Cancer

Year:

2020

File:

PDF, 726 KB

2020